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KMID : 0369819960260030215
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Jorunal of Korean Pharmaceutical Sciences
1996 Volume.26 No. 3 p.215 ~ p.219
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Antihyperlipidemic Activity of Scutellaris baicalensis Georg , Coptidis japonica Makino and Rhei koreanum Nakai on Experimental Hyperlipidemia in Rats
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노환성/Ro HS
고우경/김운자/박건구/조영환/박형섭/Ko WK/Kim OJ/Park KK/Cho YW/Park HS
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Abstract
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Active component was sought among three herb medicines, which are used in combination as a traditional medicine prescribed for patients with hyperlipidemia related diseases. Antihyperlipidemic effect of this remedy has previously been shown model by the authors on the animal model. Hyperlipidemia was induced on male Wistar rats by keeping them on high lipid diet for one week, as previously described by the authors. Blood lipid profile was verified on these rats by measuring total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Then, the diet was changed to normal. At the same time, methanol extracts of Scutellaris baicalensis Georg.(radix), Coptidis japonica Makino(rhizoma) or Rhei koreanum Nakai(rhizoma) were given on daily basis, and changes in the blood lipid profile were monitored for 4 weeks. Methanol extract of Scutellaris baicalensis Georg. significantly reduced the TC value, implying the in vivo antihyperlipidemic effect.
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KEYWORD
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